منابع مشابه
Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis.
Andrew S Greenberg*, Fredric B Kraemer, Krishnakant G Soni, Mark P Jedrychowski, Qing-Wu Yan, Christine E Graham, Thomas A Bowman and Ayla Mansur Obesity and Metabolism Laboratory, JM-USDA HNRCA, Tufts University, Boston, MA, USA, Division of Endocrinology, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA and Department of Cell Biology, Harvard Medical School, Boston,...
متن کاملGRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions
Lipid droplets are found in all cell types. Normally present at low levels in the brain, they accumulate in tumours and are associated with neurodegenerative diseases. However, little is known about the mechanisms controlling their homeostasis in the brain. We found that GRAF1a, the longest GRAF1 isoform (GRAF1 is also known as ARHGAP26), was enriched in the brains of neonates. Endogenous GRAF1...
متن کاملConsequences of Lipid Droplet Coat Protein Downregulation in Liver Cells
OBJECTIVE Accumulation of intracellular lipid droplets (LDs) in non-adipose tissues is recognized as a strong prognostic factor for the development of insulin resistance in obesity. LDs are coated with perilipin, adipose differentiation-related protein, tail interacting protein of 47 kd (PAT) proteins that are thought to regulate LD turnover by modulating lipolysis. Our hypothesis is that PAT p...
متن کاملMonoubiquitination of Ancient Ubiquitous Protein 1 Promotes Lipid Droplet Clustering
Lipid droplets, the intracellular storage organelles for neutral lipids, exist in a wide range of sizes and of morphologically distinct organization, from loosely dispersed lipid droplets to tightly packed lipid droplet clusters. We show that the lipid droplet protein AUP1 induces cluster formation. A fraction of AUP1 is monoubiquitinated at various lysine residues. This process depends on its ...
متن کاملProtein correlation profiles identify lipid droplet proteins with high confidence.
Lipid droplets (LDs) are important organelles in energy metabolism and lipid storage. Their cores are composed of neutral lipids that form a hydrophobic phase and are surrounded by a phospholipid monolayer that harbors specific proteins. Most well-established LD proteins perform important functions, particularly in cellular lipid metabolism. Morphological studies show LDs in close proximity to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Structure
سال: 2004
ISSN: 0969-2126
DOI: 10.1016/j.str.2004.04.021